Iranian Journal of Basic Medical Sciences
نویسندگان
چکیده
Article type: Original article Objective(s): HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leukocytes antigen (HLA) have been studied in different population. In the present study we examined the association between HLA-DQB1 alleles and HTLV-I infection in HAM/TSP patients, HTLV-I carriers and healthy controls in north east of Iran, Mashhad. Materials and Methods: The blood samples of 16 patients with HAM/TSP, 20 HTLV-1 carriers, and 30 healthy individuals were taken and DNA was extracted by salting out method. HLA-DQB1 typing was performed using PCR-SSP method and the frequency of HLA-DQB1 alleles were compared by Fischer Exact Test. Results: There was a significant difference between HAM/TSP patients and healthy controls in the frequency of HLA-DQB1*07 (P=0.004, RR=7). Furthermore, we found that possession of HLADQB1*02 or HLA-DQB1*05 increased the risk of disease 1.5 times. Conclusion: The data presented here suggest that both HLA-DQB1*07 and HLA-DQB1*06 are associated with disease development. Article history: Received: Apr 30, 2011 Accepted: Jul 20, 2012
منابع مشابه
A brief report on Iranian Journal of Basic Medical Sciences in 2013
This editorial deals with the state of the Iranian Journal of Basic Medical Sciences (IJBMS) in 2013. In the previous year, we received 613 manuscripts for publication. After peer-review by expert national and international reviewers, 15 % of submitted papers were accepted for publication. As presented in Figure 1, the rejection rate was around 60%. The publication frequency was doubled by swit...
متن کاملScience production in Iran: The scenario of Iranian medical journals
In Iran, the number of published articles has increased significantly in the basic and applied sciences including medicine and its subspecialties during the recent years. The present study reviewed Iranian science production in medicine, focusing on Iranian medical journals and assessing the current status of Iranian medical journals in several information databases. The study revealed that onl...
متن کاملCitation Analysis of Iranian Journal of Basic Medical Sciences in ISI Web of Knowledge, Scopus, and Google Scholar
OBJECTIVE(S) Citation tracking is an important method to analyze the scientific impact of journal articles and can be done through Scopus (SC), Google Scholar (GS), or ISI web of knowledge (WOS). In the current study, we analyzed the citations to 2011-2012 articles of Iranian Journal of Basic Medical Sciences (IJBMS) in these three resources. MATERIAL AND METHODS The relevant data from SC, GS...
متن کامل